Tuesday 15 April 2025, 17:12
A study led by the Research Institute at Del Mar de Barcelona Hospital allowed to determine one of the highly aggressive keys to pancreatic cancer. The research, published in the “PNAS” magazine, reveals the role of Galectin-1 protein in the cell nucleus that surrounds the tumor in pancreatic cancer and fibrous cells, which contribute to its activation. According to La Caixa, everything responds to Stroma, a group of cells necessary for the growth and expansion of the tumor.
“This inheritance is a major piece of aggressive biology of pancreatic cancer, because it interacts with cancer cells, protects them and prevents medicines,” says the coordinator of the research group in the new molecular goals of cancer cancer at the Research Institute at the Naval Institute and IIBB-CSIC-AIDIBAPS. In his opinion, it produces in vain cells, especially fibrous cells, “materials that prefer the tumor and facilitate growth and publication.”
To date, it was known that fibrous cells secrete the Galectin-1, a protein with protein properties. Thanks to this study, it becomes clear that the molecule “is also inside fiber cells – in the nucleus – where it plays a major role in controlling genetic expression.”
The researchers saw how Galectin-1 shows the ability to regulate the genetic expression of these cells at a very specific level, “without modifying the DNA sequence, by lagini control.” According to Navarro, one of the genes on which KRAS works, which plays in pancreatic tumors a fundamental role. Not in a bucket, this gene was also found in the cancer cells with 90 % of patients, but in this case, they are being conducted.
New molecules
Experts who have already participated in the study in previous studies have identified the main role of Galectina-1 in pancreatic cancer, but the new jobs have now discovered “opening the door to design new strategies to attack this type of tumor.”
The researchers have worked with samples of patients with pancreatic cancer and conducted experiments “in the laboratory” with fibrous human cell lines, where they investigated the effects of inhibition of both protein gene and a head. The Research Center Researcher at the Del Mar Hospital and the first to study, Judith Venksa, highlights the importance of these results: “We have proven the importance of the role of the GCTEN -1 in the cell nucleus of fiber cells, where the expression of multiple genes is organized important to the cell.”
IBYME (Conicet) and Caixaresearch Gabriel Rabinovich explains that the next steps to investigate are exploring therapeutic groups that allow Galectin-1 inhibition outside the cell and a cell.
